Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis

Receptor-mediated endocytosis.

Receptor - mediated endocytosis

In 1934, Lewis described the process ofpinocytosis an invagination of the plasma membrane enclosing a small droplet of fluid. Pinocytosis appeared to be a constitutive process, whereas phagocytosis described some years earlier by Metchnikoffwas regulated. Only within the last two decades has it been recognized that (i) during pinocytosis cells internalize vast amounts of membrane. indeed, more ...

Mechanics of receptor-mediated endocytosis.

Most viruses and bioparticles endocytosed by cells have characteristic sizes in the range of tens to hundreds of nanometers. The process of viruses entering and leaving animal cells is mediated by the binding interaction between ligand molecules on the viral capid and their receptor molecules on the cell membrane. How does the size of a bioparticle affect receptor-mediated endocytosis? Here, we...

Biomedical applications of glycosylphosphatidylinositol-anchored proteins

Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) use a unique posttranslational modification to link proteins to lipid bilayer membranes. The anchoring structure consists of both a lipid and carbohydrate portion and is highly conserved in eukaryotic organisms regarding its basic characteristics, yet highly variable in its molecular details. The strong membrane targeting property h...

Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins.

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are a functionally and structurally diverse family of post-translationally modified membrane proteins found mostly in the outer leaflet of the plasma membrane in a variety of eukaryotic cells. Although the general role of GPI-APs remains unclear, they have attracted attention because they act as enzymes and receptors in cell adhesion, dif...